2. Histaminergic mechanisms in the CNS The synergistic effect of histamine and IL-6 on NGF secretion from cultured astrocytes is evoked by histamine stimulation of IL-6 secretion via H_1-receptor-PKC-MAPK signalling pathway

摘要

Histamine is a potent stimulator of nerve growth factor (NGF) production in both the central nervous system and in the periphery. The main signalling pathway, involved in the synthesis and secretion of NGF, includes activation of histamine H_1receptor, stimulation of Ca~(2+)-dependent protein kinase C (PKC) and mitogen-activated protein (MAP) kinase [1-3]. Besides its direct stimulation of NGF production, histamine is able to stimulate it also indirectly. This effect of histamine results from its interactions with different cytokines, i.e. IL-1 beta and IL-6 which are also able to stimulate production of NGF [5, 61.