Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions,occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and 'histamine dysmetabolism'

摘要

Eosinophilic endomyocardial fibrosis (E-EMF) appears to have been first reported in 1893 in Europe , whereas an endemic variant termed tropical EMF (T-EMF) was first reported in 1946 in the Middle East . Histological studies in the 1970s demonstrated that T-EMF and E-EMF were pathologically indistinguishable . The basic lesion in E-EMF and T-EMF is obliterative ventricular endocardial fibrosis.It has been estimated that such eosinophilic heart disease accounts for 10-20% of all cardiac deaths in tropical Africa and Southeast Asia (1985118* see Materials and methods). In T-EMF patients-primarily children and young adults-peri-operative mortalities can approach 20% .