A new base substitution in the 5′ regulatory region of the humanAγ globin gene is linked with the βsgene

摘要

A new T→A base substitution, identified inside the 5′ regulatory region of the humanAγ globin gene (Aγ −499 T → A), is reported. This nucleotide change was found to be linked inciswith the mutation producing sickle cell anemia (CD6 GAG→G