Efficacy and safety of new complementary feeding guidelines with an emphasis on red meat consumption: A randomized trial in Bogota, Colombia

摘要

Background: Iron deficiency and poor linear growth are common in infants from deprived socioeconomic backgrounds and may be associated with inadequate complementary feeding (CF) practices Objective: We tested the hypothesis that new CF guidelines emphasizing meat as a source of iron and zinc would improve linear growth, iron, and zinc status in infants living in poor socioeconomic circumstances in Bogota, Colombia Design: A total of 85 term infants who were exclusively breastfed for $4 mo were randomly assigned at 6 mo of age to a control group CG (n = 43); current advice or intervention group (new guidelines group NGG (n = 42); with counseling to 1) continue breastfeeding, 2) offer red meat $3 d/wk, and 3) offer fruit and vegetables daily). Main outcomes were 1) linear growth from 6 to 12 mo of age; 2) hemoglobin, hematocrit, iron serum ferritin (SF), and zinc status at 12 mo of age; and 3) meat intake at 12 mo of age (by using a food-frequency questionnaire) Results: A total of 38 infants/group provided data at 12 mo of age NGG infants had significantly higher red meat intake mean 6 SD: 5.4 6 1.8 compared with 3.5 6 1.7 d/wk at 12 mo of age; P , 0.001), higher hemoglobin and hematocrit at 12 mo of age, and a significantly greater increase in hemoglobin (mean 6 SD change: 0.41 6 0.8 compared with 20.13 6 1.0; P = 0.01) and hematocrit (1.04 6 2.2 compared with 20.15 6 2.4; P = 0.03) from 6 to 12 mo of age than those in CG infants. There were no significant differences in linear growth from 6 to 12 mo of age or in SF or zinc Conclusions: The new guidelines showed efficacy with higher red meat intake and positive effects on hemoglobin and hematocrit. The intervention was acceptable and affordable for most mothers. These preliminary results suggest that the intervention merits investigation in a larger cohort with longer-term follow-up.