Comparative Study of Insulin Resistance and Treatment Response with Insulin Sensitizer Drug in Obese and Non-Obese Patients with Polycystic Ovary Syndrome

摘要

Aim: To compare the insulin resistance and treatment response to metformin, an insulin sensitizer drug in obese and non-obese PCOS patients. Method: 82 patients with PCOS as per Rotterdam criteria were selected and those having insulin resistance (>150microU/ml after two hours of 75 gm glucose intake) were treated with metformin for three months. Results: Insulin resistance was more prevalent among obese PCOS patients than non-obese PCOS patients. All patients, both obese and non-obese became insulin sensitive following treatment with metformin. 2 out of 3 non-obese and 5 out of 10 obese patients with OM resumed normal cycles, when obesity was determined by BMI>=30kg/m2. All non-obese patients and 5 out of 11 obese patients with OM resumed normal cycles after treatment with metformin, when obesity was determined by w.o=80cm. None achieved pregnancy. Conclusion: Metformin definitely has role in treatment of insulin resistance in both obese and non-obese PCOS patients.