SYNTHESIS OF A NEW SERIES OF AMINOMETHYLATED 5-NITRO-1H-BENZO [d] IMIDAZOLES, 6-NITROBENZO [d] OXAZOL-2(3H)-ONES AND 4-NITROISOINDOLINE- 1,3-DIONES AS ANTILEISHMANIAL AND ANTIMICROBIAL AGENTS

摘要

4-(Chlorobenzyloxy) anilines were incorporated into 5-nitro-1 H-benzo [d] imidazole, 6-nitrobenzo [d] oxazol-2(3H)-one and 4-nitroisoindoline-1,3-dione in the presence of 40% aq formaldehyde to furnish a new series of 5-nitro-1-(4-chlorobenzyloxy)-anilinomethyl-1 H-benzo [d] imidazoles / 6-nitro-3-(4-(chlorobenzyloxy)-anilinomethyl)-benzo [d] oxazol-2(3H)-ones and 4-nitro-2-(4-chlorobenzyloxy)-anilinomethyl) isoindoline-1,3-diones (11-25). The structures of the compounds were established by means of elemental analysis and spectral data (IR & PMR). Compounds were screened for their antileishmanial and antimicrobial potential.