The effects of aqueous and alkaline extracts from Agaricus blazei Murill, an edible mushroom used as folk medicine in Brazil, Japan, and China to treat several illnesses, were investigated on the basis of the inflammatory process induced by different agents. Oral administration of A. blazei extracts marginally inhibited the edema induced by nystatin. In contrast, when complete Freund's adjuvant was used as the inflammatory stimulus, both extracts were able to inhibit this process significantly (P < .05, analysis of variance followed by Tukey-Kramer multiple comparison post hoc test), although it inhibited the granulomatous tissue induction moderately. These extracts were able to decrease the ulcer wounds induced by stress. Also, administration of extracts inhibited neutrophil migration to the exudates present in the peritoneal cavity after carrageenin injection. Therefore, it is possible that A. blazei extracts can be useful in inflammatory diseases because of activation of the immune system and its cells induced by the presence of polysaccharides such as beta-glucans.
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机译：根据不同病原体诱导的炎症过程，研究了姬松茸（一种在巴西、日本和中国用作民间药物治疗多种疾病的食用蘑菇）的水性和碱性提取物的作用。口服 A. blazei 提取物略微抑制制霉菌素诱导的水肿。相反，当使用完全弗洛因德佐剂作为炎症刺激物时，两种提取物都能够显着抑制这一过程（P <.05，方差分析，然后进行Tukey-Kramer多重比较事后检验），尽管它适度抑制肉芽肿组织诱导。这些提取物能够减少由压力引起的溃疡伤口。此外，提取物的施用抑制了卡拉胶素注射后中性粒细胞迁移到腹膜腔中存在的渗出物。因此，A. blazei 提取物可能可用于炎症性疾病，因为多糖（如 β-葡聚糖）的存在会激活免疫系统及其细胞。
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