AntiHIV, Antibacterial and Antifungal Activities of Some Novel 1,4-disubstituted-1,2,4-triazolo[4,3-a] quinazolin-5(4H)-ones

摘要

The title compounds l-substimted-4-phenyl-l,2,4-triazolo[4,3-a]quinazolm-5(4H)-ones were synthesized by the cyclization of 2-hydrazino-3-phenylquinazolin-4(3H)-one with various one carbon donors. The starting material 2-hydxazino-3-phenylquinazolin-4(3H)-one was synthesized from aniline. Investigation of antimicrobial activity of the test compounds was made by agar cup-plate method against 8 pathogenic bacteria including Mycobacterium tuberculosis, 3 pathogenic fungi and antiHIV activity against replication of HIV-l(IIIB) and HIV-2(ROD) in MT-4 cells. The compound 7e inhibited 21% growth of M. tuberculosis at 6.25 ug/ml concentration, while the compounds 7c and 7d showed good antifungal activity against Candida albicans; and the compounds 7c exhibited good antifungal activity against Aspergillus niger.