Dear Sir: With great interest we read the article by Kesse-Guyot et al (1), which is presented as evidence against the beneficial long-term effects of the Mediterranean diet on cognitive aging. Our own research focuses on an Internet-mediated intervention on lifestyle changes, including improving dietary habits (2). We acknowledge the great value of a long-term follow-up study on the Mediterranean diet. This long-term follow-up on cognition, linking it to the enormous global threat of dementia in our aging societies, is the strongest point of the study. However, the long-term gap in data collection is by far the weakest point of the study, which makes the data very hard to interpret and severely jeopardizes external validity for primary prevention in daily practice.
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