A synthesis of some new 2-azetidinones as potential antitubercular agents

摘要

2-Amino-4-(#alpha#-methoxyiminocarbomethoxymethyl) thiazole 1 on condensation with different aromatic aldehyes furnishes schiff bases 2a-o which on treatment with chloroacetyl chloride in the presence of triethylamine as basic catalyst afford 2-azetidinones 3a-o. The synthesised compounds 3a-o have been tested in vitro for their antitubercular activity against Mycobacterium tuberculosis H37Rv.