A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977

摘要

A short and efficient synthesis of the potent 5-lipoxyenase inhiitor CMI-977 has been accomplished, utilishing an oxygen to carbon rearrangement of an anomerically linked alkynyl stannane tetrahydrofuranyl ether derivative as the key step.