Soluble polymer supported organic synthesis (SPSOS):Synthesis of PEG-ylated phthalizinediones

摘要

PEG-ylated phthalizine derivatives of different molecular weights have been synthesized alter the activation of PEGs using glutaric anhydride.Percentage loading has been calculated using ~1H NMR.The low molecular weight and disubstituted PEGs have been found to be more reactive as compared to the high molecular weight and tetra substituted PEGs in terms of percentage loading.