Synthesis of dibenzo(b,g)-5-methyl-1,8-naphtyrridines

摘要

A series of 1,8-naphthyridines have been synthesised.2-Hydroxy-4-methylquinoline 1 on reaction with Pcl_5POCl_3 gives 2-chloro-4-methylquinoline 2 which on treatmentwith substituted anilines yields 2-quinolinamines 3a-e.Cyclisation in situ affords the title compounds 4a-e using phosphorus oxychloride and dimethyl formamide.