Synthesis of pyrazolines and cyanopyridines as potnetial antimicrobial agents

摘要

3,3'-Bis(4-acetophenylaminosulphonyl)benzophenone 1 on condensation with various aldehydes yields chalcones 2a-p which on cyclization with hydrazine hydrate and malononitrile furnishes the corresponding 3,3'-bis(5-aryl-1H/acetyl-pyrazolin-3-yl-4-phenylaminosulphonyl)benzophenones 3a-p,3'a-p and 3,3'-bis(2-amino-3-cyano-4-aryl pyridin-6-yl-4-phenylaminosulphonyl)benzophenones 4a-p.THe structure of the compounds have been confirmed from elemental analyses,IR,~1H NMR and mass spectral data.All the products have been evaluated for their in vitro growht inhibitory activity against different microbes.