An examination of anthocyanins' and anthocyanidins' affinity for cannabinoid receptors

摘要

A growing body of evidence suggests that anthocyanins and anthocyanidins may possess analgesic properties in addition to neuroprotective and anti-inflammatory activities. These functionalities suggest a role for the cannabinoid receptor (CB) in mediating biological effects. Competitive radioligand binding assays identified cyanidin (K i=16.2 μM) and delphinidin (K i=21.3 μM) as ligands with moderate affinity to human CB1. For CB2, similar affinities were achieved by cyanidin (K i=33.5 μM), delphinidin (K i=34.3 μM), and peonidin (K i=46.4 μM). Inhibition constants >50 μM were obtained for pelargonidin, malvidin, cyanidin-3,5-di-O-glucoside, cyanidin-3-O-glucoside, cyanidin-3-O-galactoside, and cyanidin-3-O-rutinoside for both CB subtypes.