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>Whelan TJ, Olivotto I, Aekerman I, Chapman JW, Chua B, et al.: NCIC-CTG MA.20: An intergroup trial of regional nodal Irradiation in early breast cancer. J Clin Oncol 2011;29:(suppl; abstr LBA1003).
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Whelan TJ, Olivotto I, Aekerman I, Chapman JW, Chua B, et al.: NCIC-CTG MA.20: An intergroup trial of regional nodal Irradiation in early breast cancer. J Clin Oncol 2011;29:(suppl; abstr LBA1003).
Background: Randomized trials have demonstrated that locoregional radiation after mastectomy reduces locoregional recurrence and improves overall survival (OS) in women with node positive breast cancer treated with adjuvant systemic therapy. MA.20 evaluated the addition of regional nodal irradiation (RNI) to whole breast irradiation (WBI) following breast conserving surgery (BCS). Methods: Women with high risk node-negative or node-positive breast cancer treated with BCS and adjuvant chemotherapy and/or endocrine therapy were stratified by positive nodes, axillary nodes removed, chemo- and endocrine therapy and randomized to WBI (50Gy in 25 fractions +/- boost irradiation) or WBI plus RNI (45Gy in 25 fractions) to the internal mammary, supraclavicular, and high axillary lymph nodes. The primary outcome was OS. The Data Safety Monitoring Committee approved the analysis plan for the protocol specified interim analysis of relapse patterns, survival and toxicity at 5 years. Upon review of the data, they recommended release of the results.
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