Eryngium carlinaeEthanol Extract Corrects Lipid Abnormalities in Wistar Rats with Experimental Diabetes

摘要

Abnormalities in lipid metabolism, associated with increased risk of cardiovascular disease (CVD), frequently occur in people with diabetes.Eryngium carlinaeis a plant used in traditional medicine to treat lipid abnormalities. The chemical composition and hypolipidemic activity of the ethanolic extract ofE. carlinaewere analyzed to broaden our knowledge of its mechanism of action. The ethanolic extract ofE. carlinaewas tested for hypolipidemic activity by oral administration for 40 days. Atorvastatin, a widely used statin, was also administered to compare its effect with that of the extract. Serum was used for analysis of the lipid profile and liver microsomes to assess 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and low-density lipoprotein receptor (LDL-r) levels. The extract was able to reduce total cholesterol and non-high-density lipoprotein cholesterol (C-HDL) levels and increase the C-HDL levels reduced in diabetes, decreasing the atherogenic index and therefore the risk of suffering CVD at the same level as atorvastatin. The HMG-CoA reductase activity and LDL-r levels were not modified by the administration ofE. carlinae. The results demonstrate the hypolipidemic potential of ethanol extract ofE. carlinaeand support its use in traditional medicine as a hypolipidemic agent.