Botulinum Toxin Type A Inhibits alpha-Smooth Muscle Actin and Myosin II Expression in Fibroblasts Derived From Scar Contracture

摘要

Background: Scar contracture (SC) is one of the most common complications resulting from major burn injuries. Numerous treatments are currently available but they do not always yield excellent therapeutic results. Recent reports suggest that botulinum toxin type A (BTXA) is effective at reducing SC clinically, but the molecular mechanism for this action is unknown. alpha-Smooth muscle actin (alpha-SMA) and myosin II are the main components of stress fibers, which are the contractile structures of fibroblasts. The effects of BTXA on alpha-SMA and myosin II in SC are still unknown. This study aimed to explore the effect of BTXA on alpha-SMA and myosin II expression in fibroblasts derived from SC and to elucidate its actual mechanism further.