The Atg1 Ser/Thr kinase, although now a well-established regulator of autophagy, was first identified genetically in C. elegans as a requirement for axonal elongation. However, possible connections between Atg1 functions in cellular morphogenesis and in autophagy were previously unaddressed. In the recent paper highlighted in this punctum, we reconciled these dual roles for Atg1, demonstrating a requirement for p62-mediated selective autophagy in the dynamic regulation of cell shape, in both fly and mammalian macrophages, with effects on immune cell functions. This work further strengthens the emerging importance of autophagy as a post-translational regulatory mechanism in diverse cell signaling contexts, including the cortical remodeling and function of immune cells.
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机译：Atg1 Ser / Thr激酶，虽然现在已经是一个完善的自噬调节剂，但首先在秀丽隐杆线虫中被遗传鉴定为轴突伸长的必要条件。但是，以前尚未解决Atg1在细胞形态发生和自噬中的功能之间可能存在的联系。在最近在该点上突出显示的论文中，我们调和了Atg1的这些双重作用，证明了对p62介导的选择性自噬在果蝇和哺乳动物巨噬细胞中动态调节细胞形状的要求，并对免疫细胞功能产生影响。这项工作进一步增强了自噬作为翻译后调控机制在各种细胞信号传导环境中的重要性，这些机制包括皮层重塑和免疫细胞功能。
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