The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea

摘要

Background The beneficial effect of fibre intake on reducing the risk of gastric cancer (GC) has been emphasized in recent years; however, the findings from the existing literature have been ambiguous. Fibre and anti-inflammatory cytokines are associated with GC through inflammation. We investigated whether a higher fibre intake reduces GC risk and whether the IL13 rs20541 single-nucleotide polymorphism interacts with fibre intake to modify GC risk. Method In this case-control study, 377 cases and 756 controls were included to assess the effects of fibre intake and the IL13 rs20541-fibre interaction on GC risk. We collected information on fibre consumption by using a semi-quantitative food frequency questionnaire. The presence of IL13 rs20541 was determined through genetic analysis. Results A negative association between fibre intake and GC risk was observed (odds ratio (OR) = 0.37, 95% confidence interval (CI) = 0.24-0.57, P for trend < 0.001). However, the significant association seemed to be limited to males (OR = 0.28, 95% CI = 0.16-0.50, p for trend < 0.001). Although a non-significant association between IL13 rs20541 and GC risk was found (OR = 0.95, 95% CI = 0.71-1.26), we identified that individuals with a minor allele of IL13 rs20541 (AA/AG) and higher fibre intake had a lower GC risk than those with a minor allele and lower fibre intake (OR (95% CI) was 0.24 (0.12-0.45), P interaction = 0.024). Conclusion Our findings suggested a protective effect of fibre against GC carcinogenesis. However, fibre intake seemed to have a greater effect in individuals with a minor allele of IL13 rs20541 (AA/AG).