Commentary on: Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism

摘要

When J. Clifford Richardson presented the first clinical report of eight cases of progressive supranuclear palsy (PSP) at the American Neurological Association meeting in June 1963, a number of eminent discussants felt that the condition must be rare, and wondered whether a toxic aetiology might be responsible, as the cases were clustered in Ontario, Canada, With impressive foresight, Richardson remarked: 'I doubt very much that there is any local geographic incidence I expect that a good many cases of the same disease will be identified in other areas' (Steele, 1992).