Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample

摘要

Genetic variation at the lymphotoxin alpha gene (LTA), which encodes a critical mediator of the immune and inflammatory response, was first identified as a risk factor for myocardial infarct (MI) in the Japanese population by Ozaki et al. . The finding has been replicated in the same population . OzaM et al. also implicate variation in NFKBIL1 (IkBL), which is located near LTA on a shared haplotype block and bears homology to the IkB family of NFkB regulators, which exert profound influence on the immune and inflammatory responses.