In critically ill adults, supplemental parenteral nutrition reduced nosocomial infections

摘要

Question In critically ill adults, does supplementing enteral nutrition (EN) with parenteral nutrition (PN) for 5 days to achieve 100% of energy goals reduce nosocomial infection compared with EN alone? Methods Design: Randomized controlled trial (RCT); ClinicalTrials.gov NCT00802503. Allocation: Concealed. Blinding: Blinded (data collectors and statisticians). Follow-up period: 28 days. Setting: 2 medical-surgical intensive care units (ICUs) in Switzerland. Patients: 305 adults (mean age 61 y, 70% men) who had received < 60% of their energy target from EN at day 3 after ICU admission, had a functional gastrointestinal tract, expected ICU stay > 5 days, and expected survival > 7 days. Exclusion criteria included receipt of PN, persistent gastrointestinal dysfunction and ileus, or pregnancy.