Study on bioavailability of sumatriptan succinate tablets in healthy Chinese volunteers

摘要

The bioavailability of two kind of sumatriptan succinate tablets was studied in 22 healthy Chinese volunteers by crossover design. The established bioanalytical method was validated and fitted with the need for pharmacokinetic study in clinical trial. The Comparison of pharmacokinetic parameters of two kinds of sumtriptan succinate tablets after oral single dose suggested that C_(max) t_(max) and t_(1/2) had no significant difference (P_(mean)> 0.05) between test tablets and reference tablets after single dose. The relative bioavailability of the test tablets was 103.6%. Statistic analysis (two-way one-side t-test in C_(max) AUC_(0-infinity) and AUC_(0-t) result exhibited that the test tablets were bioequivalence with the reference tablets.