Changes in adipose tissue volume and distribution have been linked to the development of insulin resistance and the metabolic syndrome in non-HIV-infected individuals. These changes may occur in conjunction with obesity or disorders of altered body fat distribution, often termed lipodystrophy. Indeed, the distribution of adipose tissue is an important determinant of metabolic risk, including insulin resistance. In this regard, both increases in visceral adipose tissue (VAT) and decreases in subcutaneous adipose tissue (SAT) are independently associated with metabolic abnormalities and increased insulin resistance in non-HIV-infected adults.
展开▼
