Synthesis of Some 1,5-Benzodiazepine Derivatives as a New Class of Antimicrobial Agents

摘要

A series of ceric ammonium nitrate promoted 1,5-benzodiazapine derivatives(A-K)were synthesised and characterized by IR,~1H/~(13)C NMR,mass and elemental analysis.The in vitro antibacterial and antifungal activities of the compounds were evaluated by paper disc diffusion method.The minimum inhibitory concentration(MIC)of the compounds was also determined by agar streak dilution method.Compound E was found to exhibit the most potent in vitro antimicrobial activity with MIC of 1.2,1.2,1.3,1.2,3.2 and >100 mu g mL~(-1)against B.subtilis,P.vulgaris,K.pneumoniae,P.aeruginosa,Candida albicans.