Menorrhagia and ecchymoses in an adolescent girl treated with sertaline.

摘要

Selective serotonin reuptake inhibitors (SSRIs) are considered a first line treatment for depression and anxiety disorders in children and adolescents. In addition to their common side effects such as nausea, vomiting, diarrhea, agitation, headache, insomnia, somnolence, anxiety, and sexual dysfunction, SSRIs have also been associated with bleeding complications. Case reports have described adult patients with various bleeding disorders (e.g., ecchymoses, purpura, epistaxis), while observational studies have focused on upper gastrointestinal bleeding, intracranial bleeding, and bleeding during surgery (Weinrieb et al. 2005). Abnormal bleeding has been reported in children and adolescents taking SSRIs. Bleeding in these cases included spontaneous bruises, epistaxis, and hemorrhagic gastritis (Weinrieb et al. 2005). We report a case of an adolescent girl who manifested menorrhagia and ecchymoses after 3 weeks of sertraline treatment.