Motor cortex stimulation for ALS: Open label extension study of a previous small trial

摘要

Cortical hyperexcitability to transcranial magnetic stimulation (TMS) is an early feature of amyotrophic lateral sclerosis (ALS) that might trigger motor neuron degeneration [1]. Because circuits of human motor cortex can be modulated non-invasively using repetitive TMS (rTMS), the effects of rTMS in ALS were evaluated in several small/proof of principle studies [2—6].