Parvovirus B19 as an etiological agent of acute pleuro-pericarditis.

摘要

Infectious complications, whether associated or not with GVHD and its treatment, are a constant concern after allo-SCT. Viral infections are of particular concern because of difficulty in diagnosis, variable clinical presentation and propensity to disseminate owing to the immunological status of grafted patients. We report a case of severe pleuro-pericarditis associated with Parvovirus B19 infection in an allografted patient. A 40-year-old Caucasian man was diagnosed in April 2001 with chronic myeloid leukemia, in chronic phase. The Sokal score was low and the patient was treated with alpha-IFN and hydroxyurea, without hematological response after 6 months. Imatinib therapy was started and a hematological complete response was achieved after 1 month. Unfortunately, 4 months later, acute myeloid transformation was evident (marrow blasts 51%) and he received a classical 3 + 7 induction chemotherapy for AML, which resulted in a second chronic phase.