Hyperbaric phototherapy augments blood carbon monoxide removal

摘要

Abstract Background and Objectives Carbon monoxide (CO) poisoning is responsible for nearly 50,000 emergency department visits and 1200 deaths per year. Compared to oxygen, CO has a 250‐fold higher affinity for hemoglobin (Hb), resulting in the displacement of oxygen from Hb and impaired oxygen delivery to tissues. Optimal treatment of CO‐poisoned patients involves the administration of hyperbaric 100% oxygen to remove CO from Hb and to restore oxygen delivery. However, hyperbaric chambers are not widely available and this treatment requires transporting a CO‐poisoned patient to a specialized center, which can result in delayed treatment. Visible light is known to dissociate CO from carboxyhemoglobin (COHb). In a previous study, we showed that a system composed of six photo‐extracorporeal membrane oxygenation (ECMO) devices efficiently removes CO from a large animal with CO poisoning. In this study, we tested the hypothesis that the application of hyperbaric oxygen to the photo‐ECMO device would further increase the rate of CO elimination. Study Design/Material and Methods We developed a hyperbaric photo‐ECMO device and assessed the ability of the device to remove CO from CO‐poisoned human blood. We combined four devices into a “hyperbaric photo‐ECMO system” and compared its ability to remove CO to our previously described photo‐ECMO system, which was composed of six devices ventilated with normobaric oxygen. Results Under normobaric conditions, an increase in oxygen concentration from 21% to 100% significantly increased CO elimination from CO‐poisoned blood after a single pass through the device. Increased oxygen pressure within the photo‐ECMO device was associated with higher exiting blood PO2 levels and increased CO elimination. The system of four hyperbaric photo‐ECMO devices removed CO from 1?L of CO‐poisoned blood as quickly as the original, normobaric photo‐ECMO system composed of six devices. Conclusion This study demonstrates the feasibility and efficacy of using a hyperbaric photo‐ECMO system to increase the rate of CO elimination from CO‐poisoned blood. This technology could provide a simple portable emergency device and facilitate immediate treatment of CO‐poisoned patients at or near the site of injury.