Pancreatic atrophy is associated with gastrointestinal chronic GVHD following allogeneic PBSC transplantation.

摘要

Despite a curative treatment for hematological malignancy, allo-SCT is associated with many adverse effects in recipients. Weight loss occurs in 20-30% of patients after transplantation and is highly common among those with chronic GVHD (cGVHD). The cGVHD scoring system associates severe weight loss with a poor prognosis.1 The etiology of weight loss is not well understood at present, but is suspected to be multifactorial. Possible causes include malabsorption, decreased caloric intake, increased energy expenditure and hypercatabolism. Weight loss may be partially due to pancreatic exocrine insufficiency as seen with steatorrhea or to gastrointestinal (GI) cGVHD.5 To date, however, few reports have radiographically evaluated the pancreas of patients after SCT.