Association of C-reactive protein Levels with Fasting and Postload Glucose Levels According to Glucose Tolerance Status

摘要

Background and Aims: Several studies show that high serum C-reactive protein (CRP) levels are associated with an increased risk of diabetes, data that strongly supports a possible role for inflammation in diabetogenesis. The aim of this study was to determine whether elevated CRP levels are associated with fasting plasma glucose (FPG) and/or postload glucose levels according to the glucose tolerance status. Methods: A total of 169 healthy males and non-pregnant females aged 18-65years were enrolled in a population-based cross-sectional study. Individuals were allocated into groups with a new diagnosis of normal glucose tolerance (NGT) (n=82), impaired fasting glucose (IFG) (n=54), and impaired glucose tolerance (IGT) (n=33). Elevated CRP was defined by CRP levels >3.0 and <10.0mg/L, IFG by FPG ≥100 and <126mg/dL, and IGT by plasma glucose concentration 2h postload ≥140 and <200mg/dL. A multiple regression linear analysis adjusted by body mass index, waist circumference, and lipid profile was performed to evaluate the association between CRP levels (independent variable) with FPG and 2h postload glucose levels (dependent variables). Results: Multivariate linear regression analysis showed a significant association between hsCRP levels with FPG (β=0.536; 95% CI 1.03-5.1, p=0.005) and 2h postload glucose (β=0.209; 95% CI 1.31-2.97, p=0.01) in the IGT group, but not with FPG (β=0.147; 95% CI 0.55-2.0, p=0.25) and 2h postload glucose (β=0.151; 95% CI 0.83-3.2, p=0.24) in the IFG group. Conclusions: Elevated CRP levels are associated with FPG and 2h postload glucose in the individuals with IGT, but not in subjects with IFG or NGT.