Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trial

摘要

STUDY QUESTION Does dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergic disease reduce immunoglobulin E associated eczema or food allergy at 1 year of age?SUMMARY ANSWER n-3 LCPUFA supplementation in pregnancy did not reduce the overall incidence of immunoglobulin E associated allergies in the firstyear of life, although immunoglobulin E associated eczema was lower.WHAT IS KNOWN AND WHATTHIS PAPER ADDS Several mechanistic studies have suggested that higher intakes of n-3 LCPUFA during pregnancy modulate the neonatal immune response towards a less allergenic phenotype. n-3 LCPUFA supplementation in pregnancy did not reduce the incidence of immunoglobulin E associated food allergies in the firstyear of life, but the incidence of atopic eczema was lower.