Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies

摘要

Recurrence of SCC after treatment is low. WHAT IS KNOWN AND WHATTHIS PAPER ADDS Evidence forthe effectiveness of different treatments forSCC is generally of low quality and predominantly derived from case series. Accurate comparisons of estimates of treatment effects were not possible from the current evidence, and the significance of apparent differences between treatments should be interpreted cautiously. Selection criteria for studies We identified observational studies of all interventions for primary, non-metastatic, invasive SCC of the skin by an electronic literature search of Medline from 1948 and Embase from 1980 to 31 December 2012. Articles were restricted to those published in English.