What's new in shock? december 2013

摘要

This volume of Shock is special as it includes excellent and outstanding articles, but furthermore, this edition of Shock includes the articles of the five finalists for the 2013 new investigator award competition. It is our pleasure to write a commentary for this issue of Shock as it not only brings the latest aspects of shock science on a clinical level but also contains several basic articles that can potentially change our clinical practice. The reports in this issue range from review articles briefing the clinical rationale behind the use of freeze-dried plasma (FDP) at the point of injury, to review on lipid A analogs as an attractive family of immune modulators, and to therapeutic potential of inhibiting neutrophil mobilization in the improvement of local and remote tissue damage following ischemia-reperfusion injury (IRI). In the clinical research area, we have reports on the diagnostic value of endotoxln scattering photometry (ESP) for differentiation between sepsis and septic shock, the advantage of using activated protein С (АРС) for improving vascular reactivity, and the dynamic of lipid and protein metabolism in regulating the response to systemic inflammation and a report on the advantage of monitoring femoral arterial pressure in septic shock patients who receive high-dose norepinephrine therapy.