Successful treatment with tandem consolidation using 90yttrium- ibritumomab tiuxetan (Zevalin) and high-dose therapy with autologous PBSCT in a patient with relapsed mantle cell lymphoma presenting as multiple lymphomatous polyposis

摘要

Mantle cell lymphoma (MCL) is a relatively uncommon type of non-Hodgkin’s lymphoma, accounting for 2.5–10% of all non-Hodgkin’s lymphoma series. Most MCL cases are diagnosed in advanced Ann Arbor stage, and extranodal involvement is common. The most common extranodal site is the BM, followed by the gastrointestinal (GI) tract. Remote studies reported that GI involvement occurred in about 10–30% of MCL cases, and that multiple lymphomatous polyposis was a rare form of GI involvement. However, the actual frequency may be higher than previously reported, because endoscopy is usually performed only in patients with GI symptoms. Jorge et al. reported that GI involvement was noted in most patients with MCL.