Palladiuin(II)-Catalyzed Efficient C-3 Functionalization of Indoles with Benzylic and Allylic Alcohols under Co-Catalyst, Acid, Base, Additive and External Ligand-Free Conditions

摘要

The bis(acetonitrile)palladium(II) chloride complex, PdCl2(MeCN)2, efficiently catalyzes the regioselective alkylation of indoles with various benzylic and allylic alcohols under moisture and air insensitive conditions. Notably the reaction does not require any other co-catalyst, acid, base, additive, or external ligand.