Oxidative Heck Coupling of Allylic Amines with 2,2,6,6-Tetramethylpiperidine-N-oxyl (TEMPO) as Oxidant for the Preparation of Tetrasubstituted Alkenes

摘要

The paper describes the oxidative Heck ar-ylation of various allylic amines using arylboronic acids for the preparation of tetrasubstituted alkenes. As oxidant the commercially available 2,2,6,6-tetra-methylpiperidine-N-oxyl (TEMPO) is used and coupling reactions occur under very mild conditions at room temperature. The densely substituted alkenes are formed in good to excellent yields with complete control of the diastereoselectivity. Substrate scope with respect to the allylic amine and the arylboronic acid is investigated.