A Direct C—C Cross-Coupling of Alcohols at the β-Position with Aldehydes under Co-Promotion of Tris(triphenylphosphine)- rhodium Chloride/Boron Trifuoride Etherate

摘要

The novel tris(triphenylphosphine)rhodi-um chloride/boron trifuoride etherate [RhCl-(PPh3)3/BF3·OEt2] co-promoted the C—C cross-coupling of tertiary alcohols at the β-position with aldehydes. This reaction provides an efficient synthesis of either structurally diverse 1,3-diols or polysubsti-tuted tetrahydropyrans by controlling the substrate structures, and it could be developed to a practical synthetic method for numerous natural products and medicinally important compounds.