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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Expression of monocarboxylate transporter (MCT)-4 in colorectal cancer and its role: MCT4 contributes to the growth of colorectal cancer with vascular endothelial growth factor
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Expression of monocarboxylate transporter (MCT)-4 in colorectal cancer and its role: MCT4 contributes to the growth of colorectal cancer with vascular endothelial growth factor

机译:单羧酸盐转运蛋白(MCT)-4在结直肠癌中的表达及其作用:MCT4通过血管内皮生长因子促进结直肠癌的生长

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摘要

Background: In tumor cells, monocarboxylate transporter (MCT)-4 regulates the excretion of lactate produced by glycolysis from the cell. MCT4 has also been reported to be involved in tumor growth and infiltration. Similarly, vascular endothelial growth factor (VEGF) is known to be involved in the growth, infiltration, and metastasis of tumors. In this study, we clinically evaluated the relationship between MCT4 and VEGF in colorectal cancer. Materials and Methods: A prospective study was conducted in 210 patients with colorectal cancer who underwent surgical treatment. The clinicopathological data were correlated with the expression of MCT4 and VEGF obtained from immunohistochemical analysis. Results: MCT4 and VEGF were expressed in tumors of 102 (49%) and 129 (61%) patients, respectively. A maximum tumor diameter of 45 mm or more (p<0.0001) and a tumor invasion depth of T1 or less (p<0.0119) were factors independently correlated with the expression of MCT4 and VEGF, respectively. The tumor size was significantly smaller (p=0.0031), and the disease was significantly less advanced (p=0.0017), in MCT4-negative/VEGF- positive than MCT4-positive/VEGFnegative cases. Conclusion: We suspect that in colorectal cancer, VEGF is involved in the early stages of tumor growth and MCT4 expression appears as the tumor enlarges and contributes to its further infiltration and growth.
机译:背景:在肿瘤细胞中,单羧酸盐转运蛋白(MCT)-4调节糖酵解产生的乳酸从细胞的排泄。据报道,MCT4也参与了肿瘤的生长和浸润。同样,已知血管内皮生长因子(VEGF)参与肿瘤的生长,浸润和转移。在这项研究中,我们临床评估了MCT4和VEGF在大肠癌中的关系。材料与方法:前瞻性研究在210例接受手术治疗的大肠癌患者中进行。临床病理数据与免疫组织化学分析获得的MCT4和VEGF的表达相关。结果:MCT4和VEGF分别在102例(49%)和129例(61%)患者的肿瘤中表达。最大肿瘤直径为45mm或更大(p <0.0001)和肿瘤浸润深度为T1或更小(p <0.0119)是分别与MCT4和VEGF表达独立相关的因素。与MCT4阳性/ VEGF阴性的病例相比,MCT4阴性/ VEGF阳性的患者的肿瘤大小明显较小(p = 0.0031),疾病的进展明显较差(p = 0.0017)。结论:我们怀疑在大肠癌中,VEGF参与了肿瘤的早期生长,MCT4的表达随着肿瘤的扩大而出现,并有助于其进一步浸润和生长。

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