Antiphospholipid syndrome (APS) and heparin-induced thrombocytopenia (HIT) are 2 prothrombotic syndromes in which antibodies against complexes of charged molecules are of fundamental importance. In both syndromes, IgG antibodies directed against positively charged endogenous proteins, (32 glycoprotein I ((beta-GPI) in APS and platelet factor 4 (PF4) in HIT, are of major relevance. In APS, the antibodies are clearly autoantibodies, whereas in HIT, they are drug-induced. But at least a subset of these antibodies also shows features of autoreactivity.
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