V(D)J recombination and staggered DNA breaks: guilty again.

摘要

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, also known as MALT lymphoma, arises in extra-nodal sites. The most common sites are stomach, lung, skin, ocular adnexae, salivary glands, and thyroid gland, but virtually any extranodal site can be involved. MALT lymphoma is a prototype for antigen-driven B-cell lymphomagen-esis. Antigens involved in lymphomagenesis result from either chronic infection (eg, Helico-bacterpylori in stomach) or autoimmune diseases (eg, Hashimoto thyroiditis, Sjogren syndrome). Most extranodal sites involved by MALT lymphoma normally lack lymphoid tissue. Chronic antigenic stimulation results in these sites acquiring lymphoid tissue, within which MALT lymphomas can arise.