Semi-automated production of Zr-89-oxalate/Zr-89-chloride and the potential of Zr-89-chloride in radiopharmaceutical compounding

摘要

Interest in using Zr-89 is rapidly increasing for immuno-PET applications due to its unique characteristics and increased availability. The focus of this study was to develop an optimized semi-automated methodology for producing Zr-89-oxalate/Zr-89-chloride, and evaluate the potential application of Zr-89-chloride for radiopharmaceutical compounding. The data presented herein will be useful for the production of Zr-89-labeled radiopharmaceuticals and their compliance with regulatory issues for both preclinical and clinical use. (C) 2015 Elsevier Ltd. All rights reserved.