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首页> 外文期刊>Neurology: Official Journal of the American Academy of Neurology >Impact of plasma lipids and time on memory performance in healthy elderly without dementia.
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Impact of plasma lipids and time on memory performance in healthy elderly without dementia.

机译:血浆脂质和时间对记忆的影响在健康老年人无痴呆的表现。

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OBJECTIVE: To examine the association of plasma lipid levels to changes in cognitive function in elderly subjects without dementia. METHODS: The authors examined changes in performance in tests of memory, visuospatial/cognitive, and language abilities in 1,147 elderly individuals without dementia or cognitive impairment at baseline followed for 7 years using generalized estimating equations. RESULTS: Performance in all cognitive domains declined significantly over time, while there was no association between levels of any plasma lipid or lipid lowering treatment and memory, cognitive/visuospatial, or language performance at any interval. Higher age at baseline was related to lower scores in all three domains at each interval, while higher education and white ethnicity were associated with higher scores in all domains. Analyses relating plasma lipids to performance in color trails tests using proportional hazards regression showed no association. In subsequent analyses excluding subjects with incident dementia, memory performance declined over time, while cognitive/visuospatial and language performance did not. Higher plasma high density lipoprotein and total cholesterol were associated with higher scores in language performance at baseline; this domain declined faster among individuals with higher total cholesterol, but this result was not significant after taking multiple comparisons into account. Plasma triglycerides, low density lipoprotein, or treatment with lipid lowering agents were not associated with changes in cognitive performance. CONCLUSIONS: Plasma lipid levels or treatment with lipid lowering agents in the elderly were not associated with changes in cognitive function.
机译:目的:研究协会的等离子体血脂水平认知功能的改变老年人没有痴呆。作者研究了性能测试的变化的记忆、视觉空间的认知和语言1147年老年人没有能力在基线痴呆或认知障碍使用广义估计随访7年方程。域大幅下降,随着时间的推移,没有任何水平之间的联系血浆脂质或脂肪降低治疗和记忆,认知/视觉空间的,或语言性能在任何时间间隔。基线与所有三个中得分较低在每个区间域,而高等教育和白人种族与高有关分数在所有领域。脂质表现颜色轨迹测试使用比例风险回归没有显示协会。对象与事件痴呆、记忆性能下降随着时间的推移,认知和视觉空间的语言表现没有。和总胆固醇与高有关在语言的性能基准分数;域下降更快的个体总胆固醇高,但这个结果不是后重要的多重比较考虑在内。与脂质降低脂蛋白,或治疗代理没有与变化有关认知能力。水平与降脂类药物或治疗老年人不相关的变化认知功能。

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