Case report of a healthy, elderly man with long-term high titers for anti-acetylcholine receptor antibody without myasthenia gravis

摘要

Anti-acetylcholine receptor antibodies(AAR) are considered pathognomonic and pathogenetic for myasthenia gravis(MG).AAR detection confirms clinical diagnosis of MG.However,AAR is rarely detected in patients without MG.The underlying pathophysiological mechanisms in a normal subject without MG have not been adequately addressed in previous studies.The present study reports on a case study of a healthy,elderly man with high AAR titers for 14 years.Pathophysiological mechanisms could be due to AAR heterogeneity in specificity,affinity,and multiform,and to muscle variability in response to AAR.