Delayed amnesic syndrome after riluzole autointoxication in Huntington disease

摘要

No treatment has been shown effective in slowing Huntington disease (HD). However, the anti-glutamatergic agent riluzole has been shown to reduce chorea. Therefore, trials have been performed to study the effect of riluzole on progression of HD.In the European Huntington's Disease Initiative (EHDI) trial, patients were treated with 50 mg of riluzole (or placebo) BID. Side effects included general asthenia, nausea, and elevated serum transaminase levels. Less frequently, abdominal discomfort, dizziness, headaches, acute hepatitis, and neutropenia were noted. Little is known about the effects of riluzole overdose; both methemoglobinemiaand an amnesic syndrome have been reported only once each. We present a woman who developed an amnesic syndrome 4 days after ingestion of 3 g of riluzole.