Wnt3a nonredundantly controls hematopoietic stem cell function and its deficiency results in complete absence of canonical Wnt signaling.

摘要

Hematopoietic stem cells (HSCs) reside in specialized niches that provide signals regulating stem cell function and fate decisions. The canonical Wnt signaling pathway has been implicated in this process, but the role of specific Wnt proteins and possible functional redundancy has remained elusive.