首页> 外文期刊>Neurology: Official Journal of the American Academy of Neurology >Heterogeneity of Moyamoya disease After a decade of linkage, is there new hope for a gene?
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Heterogeneity of Moyamoya disease After a decade of linkage, is there new hope for a gene?

机译:十年后引起烟雾病的异质性基因连锁,有新的希望?

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摘要

Moyamoya disease is a rare sporadic disorder with a complex etiology. The high prevalence of moyamoya in Japan relative to other countries supports a heritable component to the disease, with about 10% of patients reporting a family history. An epidemiologic study performed in California and Washington state also showed that Asian Americans have a greater than fourfold increased incidence of moyamoya relative to whites, further supporting heritability.1 Classic linkage methods have elucidated chromosomal loci that effect susceptibility to familial moyamoya disease. Studies of Japanese affected sibling pairs and small nuclear families with moyamoya disease have suggested linkage to at least five chromosomal regions: 3p24.2-p26, 6q25, 8q23, 12pl2, and 17q25#
机译:烟雾病是一种罕见的零星的障碍一个复杂的病因。性烟雾在日本相对于其他国家支持这种疾病的遗传因素,大约10%的患者报告的一个家庭历史。加州和华盛顿州也显示亚裔美国人有超过四倍性烟雾相对发病率增加白人,进一步支持heritability.1联系方法阐明染色体位点这种效应对家族性烟雾疾病。双和小核家庭性烟雾疾病有至少五个建议链接染色体区域:3 p24.2-p26 6 q25 8 q23处,12 pl2, 17 q25 #

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