Vascular risk factors and dementia: how to move forward?

摘要

The strong attraction of MRI both visually and conceptually has to be complemented by the hard work of showing that change in an MRI measure independently correlates with the key outcome of unremitting disability. If it is not independent and not related to the key outcome, the cost and time spent by patients for MRI cannot be justified. Furthermore, demonstrating correlation is not enough and it is required that treatment-related suppression of that MRI change translates into suppression of this key outcome. We have previously assessed the clinical trial utilization of disability measures and have similar reservations.