'The heart never grows better by ''AGE''; i fear rather worse...'. Philip Stanhope, 4th Earl of Chesterfield.

摘要

Patients with renal failure and in particular patients with end-stage renal disease under chronic hemodialysis are exposed to oxidative stress , which contributes to their increased risk for cardiovascular disease and accelerated atherosclerosis, major causes of death in these patients . In fact, a major consequence related to oxidative stress, which is amplified by hemodialysis, is the oxidation of lipoproteins, which is of critical importance for the dramatic increase of atherogenetic risk in these patients . In addition, increased oxidative stress, particularly the increased production of reactive oxygen species, which results from the hemodialysis-induced activation of endothelial cells lining the lumen of the blood vessels, affects vascular tone via its destruction of vaso dilatory nitric oxide. This reduced availability of nitric oxide contributes to hypertension and cardiovascular remodeling, further increasing these patients' risk of cardiovascular disease.